Fluoroquinolone-Induced Aortic Injury

According to clinical studies, the use of fluoroquinolone antibacterial agents is associated with such rare, but serious adverse reactions as aortic injuries. The aim study was analyse scientific literature data on risk injury during treatment. analytical review showed that factors for fluoroquinolone-induced are male gender, age over 45 years, underlying disease, well smoking and atherosclerosis. Clinical morphological forms fluoroquinolone-associated injuries include dilatation (aneurysm development), dissection, rupture. analysis association between most common fluoroquinolones (ciprofloxacin, levofloxacin, moxifloxacin) development aneurysm dissection often observed least ciprofloxacin. mechanism due fluoroquinolone-mediated activation matrix metalloproteinases which damage elastic components vascular walls, reduction in lysyl oxidase expression collagen synthesis. ability form complexes magnesium ions reduces availability cell enzyme systems, delays synthesis extracellular structural proteins, leads metalloproteinase calcification walls. Prevention, early detection, timely management above-mentioned issues depend awareness different medical specialists about risks antibiotics.